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2021-07-15 15:48
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Company Profile
Greenway Biotech Co., LtdBy certification [File Integrity]
Contact:szgelinwei(Mr.)
Email:
Telephone:
Phone:
Area:Beijing
Address:Beijing
Website:http://www.greenwaybiotek.com/ http://szgelinwei.tangqian010.com/
Kojic Acid
Solubility
In Vitro |
DMSO:≥50 mg/mL(703.68 mM) |
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Preparing Stock Solutions |
Concentration/Solvent/Mass |
1 mg |
5 mg |
10 mg |
|
1 mM |
7.0368ml |
35.1840ml |
70.3680ml |
||
5 mM |
1.4074ml |
7.0368ml |
14.0736ml |
||
10 mM |
0.7037ml |
3.5184ml |
7.0368ml |
||
Please refer to the solubility information to select the appropriate solvent. | |||||
1.Add each solvent one by one: 10% DMSO >>40% PEG300 >>5% Tween-80>>45% saline |
Items |
Specifications |
Results |
Appearance Property |
Almost White or Light Yellow Crystal or Crystal line Powder |
Almost White Crystal |
Assay,% |
99.0 Min |
99.96 |
Melting Point,℃ |
152-155 |
153.6-153.7 |
Loss on Drying,% |
0. 5 Max |
0.2 |
Residue on Ignition,% |
0.10 Max |
0.05 |
Chlorides(as Cl),% |
0.005 Max |
0.005 |
Heavy Metals(as Pb),% |
0.001 Max |
0.001 |
Iron(as Fe),% |
0.001 Max |
0.001 |
Function of kojic acid
Kojic acid (cas 501-30-4) is used in the field of cosmetics. In human skin, tyrosine undergoes complex oxidation and polymerization with oxygen free radicals under the catalysis of tyrosinase, and finally synthesizes melanin. Kojic acid can inhibit the synthesis of tyrosinase, so it can strongly inhibit the formation of melanin in the skin. It is safe and non-toxic, and will not produce sequelae of leukoplakia. Therefore, Kojic acid has been formulated into lotions, facial masks, lotions, and skin creams. It can effectively treat freckles, age spots, pigmentation, acne and other high-end whitening cosmetics. Kojic acid at a concentration of 20ug/ml can inhibit 70-80% of the activity of a variety of tyrosinase (or polyphenol oxidase PPO), and the general addition amount in cosmetics is 0.5-2.0%.
Precautions for kojic acid
1. Kojic acid powder is unstable to light, heat and metal ions. Do not add it at high temperature when formulating, and control the content of iron and other metal ions in the system.
2. It is best to add appropriate complexing agents such as EDTA and antioxidants such as sodium sulfite to the system;
3. Kojic acid powder Suggested dosage : 0.5~2.0%.
http://www.greenwaybiotek.com/